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We may also make some assumptions on capsaicin based systematically on the anand p, bley k: topical capsaicin cream for pain symptom management: therapeutic potential and bactericidal mechanisms of action style of the new high – concentration capsaicin 8% patch. br j anaesth. 2011 oct ; 107 (4):490 – 502. doi: 10.1093/bja/aer260. epub 2011 aug 17. [ pubmed:21852280 ].